The Unlikely Supplement That Can Keep Your Skin Looking Healthy

Posted: August 11, 2023 | By: Shanon Peckham

Last week, we talked about the different ways your daily routine can damage your skin, and how you can protect it from sun damage, environmental pollutants, and chemical-filled products. Today, we’re taking a deep dive into one of our favorite supplements for skincare from the inside out: Muscadine Grape Extract!


Muscadine extract is derived from muscadine grapes, which grow primarily in the southeastern and south-central U.S. When it comes to antioxidants, these grapes are loaded! They rank ninth place in the USDA’s Top Antioxidant Foods list1 and they’re apparently a much sweeter, melt-in-your-mouth alternative to the standard grocery store grapes. Antioxidant-rich fruits — which you can usually pick out by their vivid orange, red, or purple color — are best known for their anti-aging and anti-inflammatory benefits.2 According to the USDA,1 “eating plenty of high-ORAC (antioxidant) fruits and vegetables — such as spinach and blueberries — may help slow the processes associated with aging in both body and brain.”

Extract from these grapes has also been studied for its potential ability to reduce the risk of heart disease, metabolic disorders, and cancer. Across several studies, muscadine extract was shown to both reduce blood pressure3 and improve blood flow.4 Additionally, the antioxidants present can help prevent oxidative damage to cells in the body,2 which is one of the leading causes of cardiovascular disease.5 A separate study was able to demonstrate a positive correlation between muscadine grape supplements and the slowing of cancer cell growth.6

Additionally, muscadine grapes have been shown to support healthy collagen levels and bone strength. In one study from 2005, researchers observed an increase in bone density, mineral content, and strength in subjects who had taken a grape seed extract supplement over six weeks.7 There is additional evidence to suggest the extract increases collagen production8 as well, which has been observed to directly contribute to higher bone mass.9


Muscadine grape seed extract can help protect and heal your body at the cellular level, but it’s more than just a powerful nutritional supplement. It’s also a must-have for healthy skin. After all, healthy skin starts with a healthy diet! As described in a brand new 2023 study, dealcoholized muscadine wine supplements visibly decreased water loss, increased elasticity, and improved smoothness of the skin in a group of women ages forty to sixty-seven.10 The underlying reason for this improvement? Researchers explained, “This is likely due to decreases in inflammation and oxidative stress.” In other words: a daily dose of concentrated antioxidants goes a long way.

When it comes to maintaining healthy skin from the inside out, these are the supplements you should consider adding to your daily routine:

Premium Muscadine Grape Seed – A convenient source of daily antioxidants that can support overall well-being and health.

Waterless Vitamin C – Our popular primer is packed with Vitamin C, which supports collagen production and wound healing.11

Muscadine 20™ Fresh Mint Toothpaste – Perfect for sensitive gums and teeth! Thanks to muscadine grapes’ phenolic compounds, this product can also help fight bacterial inflammation.12


1 Can Antioxidant Foods Forestall Aging?, U.S. Department of Agriculture, 1999

2 The importance of antioxidants and place in today’s scientific and technological studies, 2019

3 The impact of grape seed extract treatment on blood pressure changes, 2016

4 Effects of grape seed extract consumption on platelet function in postmenopausal women, 2007

5 Oxidative Stress: Harms and Benefits for Human Health, 2017

6 The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells, 2019

7 Mechanical assessment of effects of grape seed proanthocyanidins extract on tibial bone diaphysis in rats, 2005

8 Grape seed extract: having a potential health benefits, 2019

9 Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study, 2018

10 Dealcoholized Muscadine Wine Improved Skin Health, Reduced Oxidative Stress and Inflammation in Women in a Randomized Controlled Trial, 2023

11 Vitamin C Fact Sheet, NIH National Institutes of Health, Office of Dietary Supplements

12 Antioxidants of Fruit Extracts as Antimicrobial Agents against Pathogenic Bacteria, 2022

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